Job Description
POSITION SUMMARY We are seeking a full-time
Senior Bioinformatics and Data Scientist to join our team at the Buck Institute for Research on Aging to work on projects in academia with a close-knit team, collaborate with experts in the field of aging, and participate in a nationwide effort to further the field.
- The Buck Institute for Research on Aging’s Bioinformatics Core is a collaborative group of data analysis scientists who pool their knowledge and skills to provide cutting-edge services for internal and external researchers. Members cross-train to improve their data analysis skills and career development under Dr. David Furman's mentorship.
- The Program Projects Grant (PPG) “ Cellular senescence and cell fate/interactions as drivers of Alzheimer's and age-related dementias ”: focuses on how age-related changes in both neurons and non-neuronal brain cells can drive these pathologies, with the promise of developing effective interventions.
- The NIH-directed SenNet Tissue Mapping Center located at the Buck Institute for “Senescent cell mapping, identification, and validation for human somatic and reproductive tissues”: is part of a cross-consortium program to study senescent cells that play positive and negative roles in biological processes. As part of this Center, our Data Analysis Core is the nucleating facility between the Biospecimen Core, Administrative Core, and Bioanalysis Core of the U54 NIH longitudinal study of cellular senescence.
- The “ Biomarkers of Aging in Human Cohorts Project ” is a collaboration between multiple Buck Institute Principal Investigators to investigate biomarkers of aging and vaccine response in human cohorts. The Furman Lab member will help analyze metabolomics and proteomics data to consolidate vaccine response biomarkers.
KEY RESPONSIBILITIES - Perform data analysis as part of the Bioinformatics Core including:
- Omics Analysis (transcriptomics (single-cell and bulk), proteomics, metabolomics)
- Simple/Multiple Linear Regression
- Parametric and Non-parametric Statistics
- Classification Methods (random forest, SVM)
- Neural Networks
- Computer vision (Feature extraction)
- Biological Aging Calculations (Omics Clocks)
- Candidate gene studies and GWAS
- Enrichment Analysis
- Dimensionality Reduction
- Drug re-purpose
- Integrative Multi-omics
- Analyze and curate data from the SenNet project:
- Interact and coordinate between groups to ensure timely collection of data.
- Curate and upload data samples to the central repository.
- Review and improve Standard Operating Procedures (SOPs) for data transfer and management.
- Attend meetings and collaborate with NIH SenNet groups to improve upon current systems.
- Analyze and curate data from the PPG project:
- Interact and coordinate between groups to ensure timely collection of data.
- Data curation and analysis
- Collaborate with staff members, research scientists, and principal investigators.
- Grant Writing
- Journal Article Writing
- Figure Creation
QUALIFICATIONS Required Education & Experience - PhD degree in Computational Biology, Bioinformatics, or Data Science
- Minimum of 2 years professional experience in a biological field
- Proficient in R programming, Python, and Bash scripting
Other Skills - Knowledge and experience developing and running Bioinformatics workflows
- Outstanding analytical, mathematical, and creative problem-solving skills
- Excellent listening, interpersonal, written, and oral communication skills
- Logical and efficient, with keen attention to detail
- Highly self-motivated and directed; works well independently and as a team
- Ability to effectively prioritize and execute tasks
- Experience in Computer Vision
Preferred - Experience with Human data
COMPENSATION & BENEFITS - Competitive salary ($95,000 - $105,000) commensurate with experience
- Exciting, collaborative work environment at the forefront of science using state-of-the-art techniques
- Generous benefits package including health insurance, paid parental leave, generous PTO and 401(k) with 5% employer match & student debt repayment
- Work visa sponsorship available for qualified candidates
ABOUT US Our success will ultimately change healthcare. At the Buck, we aim to end the threat of age-related diseases for this and future generations by bringing together the most capable and passionate scientists from a broad range of disciplines to identify and impede the ways in which we age. We are an independent, non-profit institution located in Marin County, CA, with the goal of increasing human healthspan, or the healthy years of life. Globally recognized as the pioneer and leader in efforts to target aging—the number one risk factor for diseases including Alzheimer’s, Parkinson’s, cancer, macular degeneration, heart disease, and diabetes—the Buck seeks to help people live better longer.
TO APPLY Interested candidates should click the Apply button to complete the online application. Please upload both your CV and a document that includes a brief statement of your interests plus the names/contact information for 3 references.
Job Tags
Full time, Visa sponsorship, Work visa,